Single fiber engineers have developed a prototype at the Stanford University high color endoscope light source, increased four times more than the popular existing design resolution of the instrument. Progress may lead to thin needle era, minimally invasive instrument endoscope light source to view the characteristics of today has reached.
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The engineers at the Stanford University have shown a high resolution endoscope light source, this is a kind of high resolution than previous similar design of high resolution four times of endoscopic light. The so-called micro endoscope is an important step in the high resolution imaging, minimally invasive organisms, have potential applications in research and clinical practice. The micro endoscope can make new methods in different fields, for the study of brain cancer early detection.
The new high color endoscope light source is developed by a team under the guidance of Joseph Kahn, a professor of electrical engineering at the Stanford University College of engineering. The results of recently published in the Journal of Optical Society of optical optics and display in the United States "".
Their prototype can be solved about 2.5 micron sized objects, it is easy to reach 0.3 micron resolution. One micron is 1/1000 mm. In contrast, the high resolution of today's endoscopic light can solve the object only about 10 microns. The naked eye can see objects down to about 125 microns.
Kahn is best known for his work in the nature of the data pipeline optical fiber communication - ultra fast and large Internet data center. His work to peep mirror LED light source began two years ago when he and a Stanford University Electrical Engineer, Olaf sol high bio photonics - light field based techniques for the study of biological systems is discussed.
Olaf wants to know whether it can be achieved by a single thin such as hair fiber transmits light to form within the body of a bright spot and scan recording of living tissue image. Opportunities and challenges, Kahn and solgaard know, rest in the multimode optical fiber in the spread of light through a number of different paths, in the known optical mode; hence the name, multimode fiber. The light is transmitted through the fiber complex information, whether it is computer data or image, but it is likely to be fired on the road can not be identified on the road.
Kahn came up with a way to unlock the scrambling information through a small liquid crystal display using called spatial light modulator. To make this possible, Kahn and his research on the mahalati development of the adaptive algorithm - a dedicated computer program - by the light of the spatial light modulator learned how to interpret. A few years ago, Kahn used a similar approach to interpret the world record of transmission speed of computer data transmission through multimode optical fiber transmission.
In micro endoscope light source research happened unexpected and fortunate to when receiving celecoxib table mahalati mentioned initiated work in magnetic resonance imaging (MRI) by John poly do, another Stanford electrical engineer. The use of random sampling in the nuclear magnetic resonance image recording is greatly accelerated.
"Why don't you use a random pattern to speed up imaging through multimode fiber," said mahalati in the past " "That's it, we're on the way," Kahn. "The recording settings for the micro endoscope light source was born."
Kahn micro endoscope light source, a spatial light modulator optical fiber project random mode by in vivo irradiation object observation. The reflected light through the optical fiber to a computer. In the open computer, light reflection, power and the use of the algorithm and measures with nasiri mahalati Ruo Gu reconstructed image.
Kahn and his students were surprised to find that the number of their high color endoscope can solve the source image features four times in optical mode. Single fiber before endoscopic light limited resolution, the number of modes in the fiber, "Kahn said," so this is a four fold improvement." As a result, improve the problem of science team. "This means that, to some extent, we capture the laws of physics tell us more information can be obtained through optical fiber," Kahn. "It seems impossible." The team in a few weeks before the paradox, they came up with an explanation. The random intensity pattern combination, can be transmitted through the optical fiber mode, improve the image mode of four production four times more details. "Previous studies have overlooked mixed. We used non conventional image reconstruction algorithm is the key to reveal the hidden image details, "Kahn.
Final endoscope
Kahn and the team have created a working prototype. The main limiting factor at this point is that the fibers must remain rigid. Bending multimode fiber image recognition. Instead, the fiber is placed in a thin needle to keep its rigid insert. Rigid endoscope light source - those frequently used in surgery - are common, but they are often used in relatively thick, rod shaped lenses to produce good images. On the other hand - within the flexible endoscope illuminator for colonoscopy and ureteroscopies that - usually by single fiber tract of thousands, each transmit images of a single pixel. The two kinds of endoscope light source are bulky and limited resolution.
Single fiber endoscope such as Kahn will eventually be minimally invasive imaging system, and has been the focus of research in optical engineering in the past few years.
Kahn development of single fiber endoscope mirror light first, but in improving the resolution, it is now possible to to imagine a fiber endoscope illuminator with a diameter of about two tenths of a millimeter - than a human hair - can be solved approximately 80000 pixel resolution is about one micron thick is three. Today's best flexible optical fiber endoscope LED light source, through the comparison, the diameter of about half a millimeter, can be resolved about 10000 pixels, the resolution is about 3 microns.
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A rigid single fiber micro endoscope light source can make countless new procedures for microscopic imaging of biological. These range from the analysis of brain tissue neuronal cell biology to the study of muscle physiology and early detection of disease in various forms of cancer. Looking to the future, Kahn is a potential working with biomedical researchers develop the application of these excited, but as a physicist and engineer, he was most fascinated by creating a flexible single fiber endoscope illuminator technical challenges. "No one knows if a flexible single fiber endoscope light source is possible, but we have to try," Kahn.
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